Tripar (Trihexyphenidyl) is a centrally acting anticholinergic that blocks muscarinic receptors, with preference for the M1 subtype in the brain. It reduces cholinergic activity and may indirectly increase dopamine release in the striatum, improving motor symptoms in Parkinson's disease.
Not recommended due to lack of established safety and efficacy data.
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Tripar is used as an adjunctive therapy in managing all types of Parkinsonism, including idiopathic, arteriosclerotic, and postencephalitic. It is particularly effective when used alongside levodopa. Additionally, it is indicated to relieve extrapyramidal side effects caused by central nervous system medications such as phenothiazines, thioxanthenes, butyrophenones, and dibenzoxazepines.
Common: Dry mouth, blurred vision, dizziness, nausea, nervousness.
Serious/Rare: Cognitive impairment, urinary retention, constipation, hallucinations, glaucoma, heat intolerance, paralytic ileus, psychiatric disturbances.
Abrupt discontinuation may cause Parkinsonism rebound or Neuroleptic Malignant Syndrome (NMS).
Symptoms: Delirium, hallucinations, dry skin, blurred vision, urinary retention, cardiac issues, seizures, coma.
Management: Supportive care, gastric lavage, diazepam for agitation, avoid phenothiazines, maintain hydration and electrolyte balance.
Administration Tips: Best taken in divided doses with meals. If dry mouth is an issue, take it before meals; if nausea occurs, take it after meals. Avoid abrupt withdrawal.
Use only if needed. Unknown if excreted in breast milk. May reduce milk production; use with caution in breastfeeding women.
Keep below 30°C in a dry place away from light.
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